Intraoperative confocal laser endomicroscopy for brain tumors - potential and challenges from a neuropathological perspective.

ABSTRACT: Confocal laser endomicroscopy (CLE) represents a new non-invasive in vivo imaging technique that holds considerable promise in neurosurgery and neuropathology. CLE is based on the principle of optical sectioning which uses pinholes placed in the light path to selectively image photons of a specific focal plane by filtering out photons above and below the focal plane. Potential indications of CLE in neurosurgery and neuropathology include intraoperative tumor diagnosis and staging as well as assessment of tumor resection margins notably in the case of diffusely infiltrating gliomas. CLE-based tumor analysis in near-real time may also have a significant impact on future tumor resection strategies. We here discuss the technical features of CLE, its potential for wide-field imaging, its

SUBMITTER: Maragkou T 

PROVIDER: S-EPMC10209910 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature