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Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties.


ABSTRACT: Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were subjected to potential antidiabetic activity. The results showed that para-chloro-substituted derivative (9c) is most active with IC50 values of 10±1.56. All three compounds 9a-9c with a maximum of 20% inhibition for ALR1 represent superior selectivity toward the targeted ALR2 to act as a lead in the search for new antidiabetic agents.

SUBMITTER: Taj MB 

PROVIDER: S-EPMC10209927 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties.

Taj M B MB   Raheel A A   Alelwani W W   Alnajeebi A M AM   Alnoman R B RB   Javed T T  

Russian journal of general chemistry 20230525 4


Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were subjected to potential antidiabetic activity. The results showed that <i>para</i>-chloro-substituted derivative (<b>9c</b>) is most active with IC<sub>50</sub> values of 10±1.56. All three compounds <b>9a</b>-<b>9c</b> with a maximum of 20% inhibition for ALR  ...[more]

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