Ontology highlight
ABSTRACT:
SUBMITTER: Taj MB
PROVIDER: S-EPMC10209927 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Taj M B MB Raheel A A Alelwani W W Alnajeebi A M AM Alnoman R B RB Javed T T
Russian journal of general chemistry 20230525 4
Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were subjected to potential antidiabetic activity. The results showed that <i>para</i>-chloro-substituted derivative (<b>9c</b>) is most active with IC<sub>50</sub> values of 10±1.56. All three compounds <b>9a</b>-<b>9c</b> with a maximum of 20% inhibition for ALR ...[more]