Genetic determination of regional connectivity in modelling the spread of COVID-19 outbreak for more efficient mitigation strategies.

ABSTRACT: For the COVID-19 pandemic, viral transmission has been documented in many historical and geographical contexts. Nevertheless, few studies have explicitly modeled the spatiotemporal flow based on genetic sequences, to develop mitigation strategies. Additionally, thousands of SARS-CoV-2 genomes have been sequenced with associated records, potentially providing a rich source for such spatiotemporal analysis, an unprecedented amount during a single outbreak. Here, in a case study of seven states, we model the first wave of the outbreak by determining regional connectivity from phylogenetic sequence information (i.e. "genetic connectivity"), in addition to traditional epidemiologic and demographic parameters. Our study shows nearly all of the initial outbreak can be traced to a few lineages, ra

SUBMITTER: Salichos L 

PROVIDER: S-EPMC10209930 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature