Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor.

ABSTRACT:

Background

Migraine is a highly disabling health burden with multiple symptoms; however, it remains undertreated because of an inadequate understanding of its neural mechanisms. Neuropeptide Y (NPY) has been demonstrated to be involved in the modulation of pain and emotion, and may play a role in migraine pathophysiology. Changes in NPY levels have been found in patients with migraine, but whether and how these changes contribute to migraine is unknown. Therefore, the purpose of this study was to investigate the role of NPY in migraine-like phenotypes.

Methods

Here, we used intraperitoneal injection of glyceryl trinitrate (GTN, 10 mg/kg) as a migraine mouse model, which was verified by light-aversive test, von Frey test, and elevated plus maze test. We then performed whole-b

SUBMITTER: Yang C 

PROVIDER: S-EPMC10209951 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature