Dabrafenib-Panobinostat Salt: Improving the Dissolution Rate and Inhibition of BRAF Melanoma Cells.

ABSTRACT: Cocrystallization of the drug-drug salt-cocrystal of the histone deacetylase inhibitor (HDACi) panobinostat (PAN) and b-rapidly accelerated fibrosarcoma (BRAF) inhibitor dabrafenib (DBF) afforded single crystals of a two-drug salt stabilized by N⁺-H···O and N⁺-H···N^- hydrogen bonds between the ionized panobinostat ammonium donor and dabrafenib sulfonamide anion acceptor in a 12-member ring motif. A faster dissolution rate for both drugs was achieved through the salt combination compared to the individual drugs in an aqueous acidic medium. The dissolution rate exhibited a peak concentration (C_max) of approximately 310 mg cm^-2 min^-1 for PAN and 240 mg cm^-2 min^-1 for DBF at a T_max

SUBMITTER: Rai SK 

PROVIDER: S-EPMC10210236 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature