METTL3 and STAT3 form a positive feedback loop to promote cell metastasis in hepatocellular carcinoma.

ABSTRACT:

Background

It is well-established that most Hepatocellular carcinoma (HCC) patients die of metastasis, yet the potential mechanisms orchestrating metastasis remain poorly understood. Current evidence suggests that the dysregulation of METTL3-mediated m6A methylation modification is closely associated with cancer progression. STAT3 is an oncogenic transcription factor that reportedly plays a central role in the occurrence and development of HCC. However, the relationship between METTL3 and STAT3 in HCC metastasis remains unclear.

Methods

The relationship between METTL3 expression and the survival of HCC patients was assessed by online tools GEPIA and Kaplan-Meier Plotter. Western blotting, Tissue microarray (TMA), and immunohistochemistry (IHC) staining were used to evaluate

SUBMITTER: Liu B 

PROVIDER: S-EPMC10210303 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature