Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels.

ABSTRACT: Delta-9-tetrahydrocannabinol (Δ⁹-THC) is known to produce systemic analgesia that involves CB₁ and CB₂ cannabinoid receptors. However, there is compelling evidence that Δ⁹-THC can potently inhibit Cav3.2T-type calcium channels which are highly expressed in dorsal root ganglion neurons and in the dorsal horn of the spinal cord. Here, we investigated whether spinal analgesia produced by Δ⁹-THC involves Cav3.2 channels vis a vis cannabinoid receptors. We show that spinally delivered Δ⁹-THC produced dose-dependent and long-lasting mechanical anti-hyperalgesia in neuropathic mice, and showed potent analgesic effects in models of inflammatory pain induced by formalin or Complete Freund's Adjuvant (CFA) injection into the hind paw,

SUBMITTER: de Maria Gadotti V 

PROVIDER: S-EPMC10210369 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature