Tau accumulation in autosomal dominant Alzheimer's disease: a longitudinal [¹⁸F]flortaucipir study.

ABSTRACT: Cortical tau accumulation is a key pathological event that partly defines Alzheimer's disease (AD) onset and is associated with cognitive decline and future disease progression. However, an improved understanding of the timing and pattern of early tau deposition in AD and how this may be tracked in vivo is needed. Data from 59 participants involved in two longitudinal cohort studies of autosomal dominant AD (ADAD) were used to investigate whether tau PET can detect and track presymptomatic change; seven participants were symptomatic, and 52 were asymptomatic but at a 50% risk of carrying a pathogenic mutation. All had baseline flortaucipir (FTP) PET, MRI and clinical assessments; 26 individuals had more than one FTP PET scan. Standardised uptake value ratios (SUVRs) in prespecified regions

SUBMITTER: O'Connor A 

PROVIDER: S-EPMC10210376 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature