Reduced CCR5 expression among Uganda HIV controllers.

ABSTRACT:

Background

Several mechanisms including reduced CCR5 expression, protective HLA, viral restriction factors, broadly neutralizing antibodies, and more efficient T-cell responses, have been reported to account for HIV control among HIV controllers. However, no one mechanism universally accounts for HIV control among all controllers. In this study we determined whether reduced CCR5 expression accounts for HIV control among Ugandan HIV controllers. We determined CCR5 expression among Ugandan HIV controllers compared with treated HIV non-controllers through ex-vivo characterization of CD4 + T cells isolated from archived PBMCs collected from the two distinct groups.

Results

The percentage of CCR5 + CD4 + T cells was similar between HIV controllers and treated HIV non-controllers

SUBMITTER: Nyiro B 

PROVIDER: S-EPMC10210444 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature