Sex-biased gene expression at single-cell resolution: cause and consequence of sexual dimorphism.

ABSTRACT: Gene expression differences between males and females are thought to be key for the evolution of sexual dimorphism, and sex-biased genes are often used to study the molecular footprint of sex-specific selection. However, gene expression is often measured from complex aggregations of diverse cell types, making it difficult to distinguish between sex differences in expression that are due to regulatory rewiring within similar cell types and those that are simply a consequence of developmental differences in cell-type abundance. To determine the role of regulatory versus developmental differences underlying sex-biased gene expression, we use single-cell transcriptomic data from multiple somatic and reproductive tissues of male and female guppies, a species that exhibits extensive phenotypic s

SUBMITTER: Darolti I 

PROVIDER: S-EPMC10210449 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature