Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals.

ABSTRACT:

Background

Thrombocytopenia due to hypersplenism is a major complication of hepatitis C virus (HCV)-associated cirrhosis. HCV eradication improves these complications in some patients, but the long-term effects of HCV eradication on these complications remain unclear, especially in patients treated with direct acting antivirals (DAAs). The aim was to evaluate long term changes in thrombocytopenia and leucopenia after HCV eradication with DAAs.

Methods

The present multicenter study retrospectively evaluated changes over 5 years in thrombocytopenia and leukocytopenia, as well as changes in liver fibrosis markers and spleen size, in 115 patients with HCV-cirrhosis treated with DAAs.

Results

Thrombocytopenia and leukocytopenia were improved 4 weeks after DAA administratio

SUBMITTER: Tajiri K 

PROVIDER: S-EPMC10210476 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature