Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study.

ABSTRACT:

Background

Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFR_crea) have been applied in various study populations with different age ranges. This has shown that PGS explain less eGFR_crea variance in the elderly. Our aim was to understand how differences in eGFR variance and the percentage explained by PGS varies between population of general adults and elderly.

Results

We derived a PGS for cystatin-based eGFR (eGFR_cys) from published genome-wide association studies. We used the 634 variants known for eGFR_crea and the 204 variants identified for eGFR_cys to calculate the PGS in two comparable studies capturing a general adult and an eld

SUBMITTER: Herold JM 

PROVIDER: S-EPMC10210501 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature