Self-Regulated and Bidirectional Communication in Synthetic Cell Communities.

ABSTRACT: Cell-to-cell communication is not limited to a sender releasing a signaling molecule and a receiver perceiving it but is often self-regulated and bidirectional. Yet, in communities of synthetic cells, such features that render communication efficient and adaptive are missing. Here, we report the design and implementation of adaptive two-way signaling with lipid-vesicle-based synthetic cells. The first layer of self-regulation derives from coupling the temporal dynamics of the signal, H₂O₂, production in the sender to adhesions between sender and receiver cells. This way the receiver stays within the signaling range for the duration sender produces the signal and detaches once the signal fades. Specifically, H₂O₂ acts as both a forward signal and

SUBMITTER: Ji Y 

PROVIDER: S-EPMC10210537 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature