Case Report: Early detection of pancreatic pre-cancer lesion in multimodal approach with exosome liquid biopsy.

ABSTRACT:

Background

The detection of pancreatic ductal adenocarcinoma (PDAC) lesions at pre-cancerous or early-stages is critical to improving patient survival. We have developed a liquid biopsy test (ExoVita^®) based on the measurement of protein biomarkers in cancer-derived exosomes. The high sensitivity and specificity of the test for early-stage PDAC has the potential to improve a patient's diagnostic journey in hopes to impact patient outcomes.

Methods

Exosome isolation was performed using alternating current electric (ACE) field applied to the patient plasma sample. Following a wash to eliminate unbound particles, the exosomes were eluted from the cartridge. A downstream multiplex immunoassay was performed to measure proteins of interest on the exosomes, and a proprie

SUBMITTER: Dhani H 

PROVIDER: S-EPMC10210587 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature