Intraoperative Fraction of Inspired Oxygen and Lung Injury in Coronary Artery Bypass Grafting: Study Protocol for a Randomised Controlled Trial.

ABSTRACT:

Objective

Postoperative pulmonary complications are a series of disorders that can contribute to respiratory distress and prolonged mechanical ventilation postoperatively. We hypothesise that a liberal oxygenation strategy during cardiac surgery leads to a higher incidence of postoperative pulmonary complications than a restrictive oxygenation strategy.

Methods

This study is a prospective, observer-blinded, centrally randomised and controlled, international multicentre clinical trial.

Results

After obtaining a written informed consent, 200 adult patients undergoing coronary artery bypass grafting will be enrolled and randomised to receive either restrictive or liberal oxygenation perioperatively. The liberal oxygenation group will receive 1.0 fraction of inspired oxyg

SUBMITTER: Song K 

PROVIDER: S-EPMC10210611 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature