Regeneration and developmental enhancers are differentially compatible with minimal promoters.

ABSTRACT: Enhancers and promoters are cis-regulatory elements that control gene expression. Enhancers are activated in a cell type-, tissue-, and condition-specific manner to stimulate promoter function and transcription. Zebrafish have emerged as a powerful animal model for examining the activities of enhancers derived from various species through transgenic enhancer assays, in which an enhancer is coupled with a minimal promoter. However, the efficiency of minimal promoters and their compatibility with multiple developmental and regeneration enhancers have not been systematically tested in zebrafish. Thus, we assessed the efficiency of six minimal promoters and comprehensively interrogated the compatibility of the promoters with developmental and regeneration enhancers. We found that the fos minim

SUBMITTER: Begeman IJ 

PROVIDER: S-EPMC10211259 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature