Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control.

ABSTRACT: The baroreflex is a multi-input, multi-output control physiological system that regulates blood pressure by modulating nerve activity between the brainstem and the heart. Existing computational models of the baroreflex do not explictly incorporate the intrinsic cardiac nervous system (ICN), which mediates central control of the heart function. We developed a computational model of closed-loop cardiovascular control by integrating a network representation of the ICN within central control reflex circuits. We examined central and local contributions to the control of heart rate, ventricular functions, and respiratory sinus arrhythmia (RSA). Our simulations match the experimentally observed relationship between RSA and lung tidal volume. Our simulations predicted the relative contributions of

SUBMITTER: Gee MM 

PROVIDER: S-EPMC10211393 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature