Trajectories of depressive symptoms through adolescence as predictors of cortical thickness in the orbitofrontal cortex: An examination of sex differences.

ABSTRACT: Previous research has found associations between orbitofrontal cortex (OFC) structure and symptoms of major depression, though specific aspects of this complex relationship remain unclear. The current study examined sex differences in the influence of individual trajectories of depressive symptoms on cortical thickness (CT) in the OFC during late adolescence. Fifty-four participants enrolled in an ongoing longitudinal study completed assessments of depression symptoms at baseline (M_age = 12.09; SD = 1.06) and at 6-month intervals through adolescence, followed by an MRI assessment (M_age = 17.34; SD = 0.98). Estimates of CT in the OFC were obtained using FreeSurfer. Multilevel modeling (MLM) analyses estimated individuals' symptom trajectories, and identified significan

SUBMITTER: Nielsen JD 

PROVIDER: S-EPMC10211395 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature