Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study.

ABSTRACT:

Objectives

Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and by compromised interhemispheric connectivity.

Methods

We studied these issues in 52 ADHD and 43 non-clinical adults by comparing: (1) stop-signal reaction time (SSRT); (2) frontal asymmetry of the N200 event-related potential component, which is evoked during response inhibition and is lateralised to the right hemisphere; (3) TMS-evoked potential (TEP) in the right frontal hemisphere, which is indicative of local cortical excitability; and (4) frontal right-to-left interhemispheric TMS signal propaga

SUBMITTER: Avnit A 

PROVIDER: S-EPMC10212190 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature