Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses.

ABSTRACT:

Background

Frailty is a prevalent state associated with several aging-related traits and conditions. The relationship between frailty and stroke remains understudied. Here we aim to investigate whether the hospital frailty risk score (HFRS) is associated with the risk of stroke and determine whether a significant association between genetically determined frailty and stroke exists.

Design

Observational study using data from All of Us research program and Mendelian Randomization analyses.

Methods

Participants from All of Us with available electronic health records were selected for analysis. All of Us began national enrollment in 2018 and is expected to continue for at least 10 years. All of Us is recruiting members of groups that have tradi

SUBMITTER: Renedo D 

PROVIDER: S-EPMC10212531 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature