Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population.

ABSTRACT: The mouse brain is by far the most intensively studied among mammalian brains, yet basic measures of its cytoarchitecture remain obscure. For example, quantifying cell numbers, and the interplay of sex, strain, and individual variability in cell density and volume is out of reach for many regions. The Allen Mouse Brain Connectivity project produces high-resolution full brain images of hundreds of brains. Although these were created for a different purpose, they reveal details of neuroanatomy and cytoarchitecture. Here, we used this population to systematically characterize cell density and volume for each anatomical unit in the mouse brain. We developed a DNN-based segmentation pipeline that uses the autofluorescence intensities of images to segment cell nuclei even within the densest regi

SUBMITTER: Elkind D 

PROVIDER: S-EPMC10212558 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature