Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation.

ABSTRACT: Borna disease virus (BDV) causes CD8(+) T-cell-mediated meningoencephalitis in immunocompetent mice and rats, thus providing a valuable animal model for studying the mechanisms of virus-induced central nervous system (CNS) immunopathology. Chemokine-mediated leukocyte recruitment to the CNS is a crucial step in the development of neurological disease. We found increased mRNA levels of IP-10 and other chemokines in brains of adult rats following infection with BDV. The marked increase in chemokine gene expression at about day 8 postinfection seemed to immediately precede the inflammatory process. In brains of rats infected as newborns, in which inflammation was only mild and transient, sustained expression of IP-10 and RANTES genes was observed. In situ hybridization studies revealed that a

SUBMITTER: Sauder C 

PROVIDER: S-EPMC102126 | biostudies-literature | 2000 Oct

REPOSITORIES: biostudies-literature