Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells.

ABSTRACT: Epithelial cells form continuous membranous structures for organ formation, and these cells are classified into three major morphological categories: cuboidal, columnar, and squamous. It is crucial that cells transition between these shapes during the morphogenetic events of organogenesis, yet this process remains poorly understood. All three epithelial cell shapes can be found in the follicular epithelium of Drosophila egg chamber during oogenesis. Squamous cells (SCs) are initially restricted to the anterior terminus in cuboidal shape. They then rapidly become flattened to assume squamous shape by stretching and expansion in 12 ​h during midoogenesis. Previously, we reported that Notch signaling activated a zinc-finger transcription factor Broad (Br) at the end of early oogenesis. Here w

SUBMITTER: Jia D 

PROVIDER: S-EPMC10212604 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature