M⁶ A promotes planarian regeneration.

ABSTRACT: Regeneration is the regrowth of damaged tissues or organs, a vital process in response to damages from primitive organisms to higher mammals. Planarian possesses active whole-body regenerative capability owing to its vast reservoir of adult stem cells, neoblasts, providing an ideal model to delineate the underlying mechanisms for regeneration. RNA N⁶ -methyladenosine (m⁶ A) modification participates in many biological processes, including stem cell self-renewal and differentiation, in particular the regeneration of haematopoietic stem cells and axons. However, how m⁶ A controls regeneration at the whole-organism level remains largely unknown. Here, we demonstrate that the depletion of m⁶ A methyltransferase regulatory subunit wtap abolishes plana

SUBMITTER: Cui G 

PROVIDER: S-EPMC10212710 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature