The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer.

ABSTRACT: One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3⁺CD8⁺ T cell-inflamed tumors typically show better response to immune checkpoint inhibitors, it is still unknown whether the immunopeptidome repertoire presented in highly inflamed and noninflamed tumors is substantially different. We surveyed 61 tumor regions and adjacent nonmalignant lung tissues from 8 patients with lung cancer and performed deep antigen discovery combining immunopeptidomics, genomics, bulk and spatial transcriptomics, and explored the heterogeneous expression and presentation of tumor (neo)antigens. In the present study, we associated diverse immune cell populatio

SUBMITTER: Kraemer AI 

PROVIDER: S-EPMC10212769 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature