Impacts of residual 3D printing metal powders on immunological response and bone regeneration: an in vivo study.

ABSTRACT: Residual powder is a defect in powder bed fusion-based additive manufacturing (3D printing), and it is difficult to completely remove it from as-printed materials. In addition, it is not necessary to apply 3D printed implants with residual powder in the clinic. The immunological response triggered by the residual powder is an important area of study in medical research. To further understand the possible immunological reactions and hidden dangers caused by residual powders in vivo, this study compared the immunological reactions and osteolysis caused by typical powders for four implant materials: 316 L stainless steel, CoCrMo, CP-Ti, and Ti-6Al-4V (particle size range of 15-45 μm), in a mouse skull model. Furthermore, the possible immunological responses and bone regeneration induced by th

SUBMITTER: Tang J 

PROVIDER: S-EPMC10212846 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature