Ontology highlight
ABSTRACT:
SUBMITTER: Di Ianni A
PROVIDER: S-EPMC10213020 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Di Ianni Alessio A Tüting Christian C Kipping Marc M Ihling Christian H CH Köppen Janett J Iacobucci Claudio C Arlt Christian C Kastritis Panagiotis L PL Sinz Andrea A
Scientific reports 20230525 1
The tetrameric tumor suppressor p53 represents a great challenge for 3D-structural analysis due to its high degree of intrinsic disorder (ca. 40%). We aim to shed light on the structural and functional roles of p53's C-terminal region in full-length, wild-type human p53 tetramer and their importance for DNA binding. For this, we employed complementary techniques of structural mass spectrometry (MS) in an integrated approach with computational modeling. Our results show no major conformational di ...[more]