Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats' choroid plexus.

ABSTRACT: Manganese dioxide nanoparticles (MnO₂-NPs) have a wide range of applications in biomedicine. Given this widespread usage, it is worth noting that MnO₂-NPs are definitely toxic, especially to the brain. However, the damage caused by MnO₂-NPs to the choroid plexus (CP) and to the brain after crossing CP epithelial cells has not been elucidated. Therefore, this study aims to investigate these effects and elucidate potential underlying mechanisms through transcriptomics analysis. To achieve this objective, eighteen SD rats were randomly divided into three groups: the control group (control), low-dose exposure group (low-dose) and high-dose exposure group (high-dose). Animals in the two treated groups were administered with two concentrations of MnO₂-

SUBMITTER: Memg CY 

PROVIDER: S-EPMC10213021 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature