Systematic evaluation of a predator stress model of depression in mice using a hierarchical 3D-motion learning framework.

ABSTRACT: Investigation of the neurobiology of depression in humans depends on animal models that attempt to mimic specific features of the human disorder. However, frequently-used paradigms based on social stress cannot be easily applied to female mice which has led to a large sex bias in preclinical studies of depression. Furthermore, most studies focus on one or only a few behavioral assessments, with time and practical considerations prohibiting a comprehensive evaluation. In this study, we demonstrate that predator stress effectively induced depression-like behaviors in both male and female mice. By comparing predator stress and social defeat models, we observed that the former elicited a higher level of behavioral despair and the latter elicited more robust social avoidance. Furthermore, the u

SUBMITTER: Tseng YT 

PROVIDER: S-EPMC10213065 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature