Comparison of multiple synthetic chondroinductive factors in pellet culture against a TGF-β positive control

ABSTRACT: Despite the advances in surgical and cell therapy regenerative techniques for cartilage repair, the challenge is to overcome an inferior fibrocartilage repair tissue. In vitro, TGF-β1 and TGF-β3 are the primary growth factors employed to induce chondrogenic differentiation. However, the clinical application of native proteins may present challenges regarding stability, cost, or reproducibility. Therefore, there remains an unmet clinical need for the identification of small chondroinductive synthetic molecules. From the literature, two peptides—CM10 and CK2.1—appear to be promising candidates; however, they have not been directly compared to TGF-β with human bone marrow-derived stem cells (hBMSCs). Similarly, two promising compounds—kartogenin and SM04690—have been reported in the literatur

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PROVIDER: S-EPMC10213102 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature