Development and optimisation of a preclinical cone beam computed tomography-based radiomics workflow for radiation oncology research.

ABSTRACT:

Background and purpose

Radiomics features derived from medical images have the potential to act as imaging biomarkers to improve diagnosis and predict treatment response in oncology. However, the complex relationships between radiomics features and the biological characteristics of tumours are yet to be fully determined. In this study, we developed a preclinical cone beam computed tomography (CBCT) radiomics workflow with the aim to use in vivo models to further develop radiomics signatures.

Materials and methods

CBCT scans of a mouse phantom were acquired using onboard imaging from a small animal radiotherapy research platform (SARRP, Xstrahl). The repeatability and reproducibility of radiomics outputs were compared across different imaging protocols, segmentation si

SUBMITTER: Brown KH 

PROVIDER: S-EPMC10213103 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature