Opportunities and limitations for studying neuropsychiatric disorders using patient-derived induced pluripotent stem cells.

ABSTRACT: Neuropsychiatric disorders affect a large proportion of the global population and there is an urgent need to understand the pathogenesis and to develop novel and improved treatments of these devastating disorders. However, the diverse symptomatology combined with complex polygenic etiology, and the limited access to disorder-relevant cell types in human brains represent a major obstacle for mechanistic disease research. Conventional animal models, such as rodents, are limited by inherent species differences in brain development, architecture, and function. Advances in human induced pluripotent stem cells (hiPSCs) technologies have provided platforms for new discoveries in neuropsychiatric disorders. First, hiPSC-based disease models enable unprecedented investigation of psychiatric disorde

SUBMITTER: Hong Y 

PROVIDER: S-EPMC10213114 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature