Microbial Changes Associated With Oral Cavity Cancer Progression.

ABSTRACT:

Objective

To examine the oral microbiome in the context of oral cavity squamous cell carcinoma.

Study design

Basic science research.

Setting

Academic medical center.

Methods

Oral swabs were collected from patients presenting to the operating room for management of oral cavity squamous cell carcinoma and from age- and sex-matched control patients receiving surgery for unrelated benign conditions. 16S ribosomal RNA (rRNA) sequencing was performed on genetic material obtained from swabs. A bacterial rRNA gene library was created and sequence reads were sorted into taxonomic units.

Results

Thirty-one control patients (17 males) and 35 cancer patients (21 males) were enrolled. Ages ranged from 23 to 89 (median 63) for control patients and 35 to 86 (median 66)

SUBMITTER: Yan K 

PROVIDER: S-EPMC10213157 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature