Sympathetic neuropathology is revealed in muscles affected by amyotrophic lateral sclerosis.

ABSTRACT: Rationale: The anatomical substrate of skeletal muscle autonomic innervation has remained underappreciated since it was described many decades ago. As such, the structural and functional features of muscle sympathetic innervation are largely undetermined in both physiology and pathology, mainly due to methodological limitations in the histopathological analysis of small neuronal fibers in tissue samples. Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease which mainly targets motor neurons, and despite autonomic symptoms occurring in a significant fraction of patients, peripheral sympathetic neurons (SNs) are generally considered unaffected and, as such, poorly studied. Purpose: In this research, we compared sympathetic innervation of normal and ALS muscles,

SUBMITTER: Mazzaro A 

PROVIDER: S-EPMC10213213 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature