An estrogen response-related signature predicts response to immunotherapy in melanoma.

ABSTRACT:

Background

Estrogen/estrogen receptor signaling influences the tumor microenvironment and affects the efficacy of immunotherapy in some tumors, including melanoma. This study aimed to construct an estrogen response-related gene signature for predicting response to immunotherapy in melanoma.

Methods

RNA sequencing data of 4 immunotherapy-treated melanoma datasets and TCGA melanoma was obtained from open access repository. Differential expression analysis and pathway analysis were performed between immunotherapy responders and non-responders. Using dataset GSE91061 as the training group, a multivariate logistic regression model was built from estrogen response-related differential expression genes to predict the response to immunotherapy. The other 3 datasets of immunotherapy-

SUBMITTER: Lin M 

PROVIDER: S-EPMC10213284 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature