Clinical characteristics and primary outcomes of patients with ANCA-associated vasculitis and central diabetes insipidus

ABSTRACT:

Introduction

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by systemic small-vessel vasculitis and may rarely present as central diabetes insipidus (CDI). In this study, we aimed to determine the clinical characteristics and prognosis of patients with AAV-associated CDI.

Methods

This was a nested case-control study where AAV patients with CDI at the Peking Union Medical College Hospital were followed from January 2012 to April 2022. Case-control matching with AAV patients without CDI was performed (1:5), and participants were matched by age, sex, and AAV classification. We collected clinical data every 3–6 months and conducted a literature review using PubMed to identify relevant articles published from 1983–2022.

Results

SUBMITTER: Chen X 

PROVIDER: S-EPMC10213315 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature