Lipoprotein(a) and stroke: a two-sample Mendelian randomization study.

ABSTRACT:

Background

To evaluate the causal relationship between lipoprotein(a) Lp(a) and stroke risk.

Method

Adopting two grand scale genome-wide association study (GWAS) databases, the instrumental variables were selected on the basis that the genetic loci met the criteria of being independent of each other and closely related to Lp(a). Summary-level data for outcomes, ischemic stroke and its subtypes were acquired from the UK Biobank and MEGASTROKE consortium databases. Two-sample MR analyses were achieved using inverse variance-weighted (IVW) meta-analysis (primary analysis), weighted median analysis, and the MR Egger regression method. Multivariable-adjusted Cox regression models were also used for observational analysis.

Result

Genetically predicted Lp(a) was marginally r

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10213338 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature