Visual reading for [¹⁸F]Florzolotau ([¹⁸F]APN-1607) tau PET imaging in clinical assessment of Alzheimer's disease.

ABSTRACT:

Introduction

Tau-targeted positron emission tomography (tau-PET) is a potential tool for the differential diagnosis of Alzheimer's disease (AD) and to clarify the distribution of tau deposition. In addition to the quantitative analysis of tau-PET scans, visual reading supports the assessment of tau loading for clinical diagnosis. This study aimed to propose a method for visually interpreting tau-PET using the [¹⁸F] Florzolotau tracer and investigate the performance and utility of the visual reading.

Materials and methods

A total number of 46 individuals with 12 cognitively unimpaired subjects (CU), 20 AD patients with mild cognitive impairment (AD-MCI), and 14 AD with dementia (AD-D) patients with both [¹⁸F]Florbetapir amyloid PET and [¹⁸F]Fl

SUBMITTER: Lin HC 

PROVIDER: S-EPMC10213356 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature