Derivation and validation of a nutrition-covered prognostic scoring system for extranodal NK/T-cell lymphoma.

ABSTRACT:

Introduction

Patients with aggressive lymphomas are at high risk of losing body resources, resulting in malnutrition, immunodeficiency and inferior outcomes. Nutritional status is closely associated with survival, but often neglected in the prognostic assessment. This study aimed to explore the significance of nutritional status in extranodal NK/T-cell lymphoma (ENKTL).

Methods

Univariate and multivariate Cox regression analyses were conducted to examine the significance of nutritional index on overall survival (OS) and progression-free survival (PFS). A nutrition-incorporated score system was constructed based on the multivariate results, and its calibration, discrimination and clinical utility were tested in the training and validation cohort.

Results

Multivariate a

SUBMITTER: Lu T 

PROVIDER: S-EPMC10213411 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature