Impact of redox-related genes on tumor microenvironment immune characteristics and prognosis of high-grade gliomas

ABSTRACT:

Introduction

High-grade glioma (HGG) defines a group of brain gliomas characterized by contrast enhancement, high tumor heterogeneity, and poor clinical outcome. Disturbed reduction–oxidation (redox) balance has been frequently associated with the development of tumor cells and their microenvironment (TME).

Methods

To study the influence of redox balance on HGGs and their microenvironment, we collected mRNA-sequencing and clinical data of HGG patients from TCGA and CGGA databases and our own cohort. Redox-related genes (ROGs) were defined as genes in the MSigDB pathways with keyword “redox” that were differentially expressed between HGGs and normal brain samples. Unsupervised clustering analysis was used to discover ROG expression clusters. Over-representation analysis (O

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC10213429 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature