Comprehensive analysis of untargeted metabolomics and lipidomics in girls with central precocious puberty

ABSTRACT:

Objective

Central precocious puberty (CPP) is a rare condition that causes early sexual development in children. Although the cure is effective, the etiology of central precocious puberty is unclear.

Methods

In total, 10 girls with central precocious puberty and same number of age-matched female controls were enrolled. Plasma samples were collected from each participant and subjected to untargeted metabolomics and lipidomics. Student's t-tests were employed to compare the mean of each metabolite and lipid. Furthermore, orthogonal partial least-squares discriminant analysis was conducted and the variable importance in the projection was calculated to identify differentially expressed metabolites or lipids. Subsequent bioinformatics was conducted to investigate the potentia

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10213437 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature