Hyperthermia intravesical chemotherapy acts as a promising alternative to bacillus Calmette–Guerin instillation in non-muscle-invasive bladder cancer: a network meta-analysis

ABSTRACT:

Introduction

With the shortage of bacillus Calmette–Guérin (BCG) vaccine, it is important to find an alternative to BCG instillation, which is the most commonly used adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC) patients after transurethral resection of bladder tumor treatment (TURBt) to delay tumor recurrence. Hyperthermia intravesical chemotherapy (HIVEC) with mitomycin C (MMC) is a potential treatment choice. We aim to compare HIVEC with BCG instillation for the preventive efficacy of bladder tumor recurrence and progression.

Methods

A network meta-analysis (NMA) was taken with MMC instillation and TURBt as the attached comparators. Randomized controlled trials (RCTs) with NIMBC patients after TURBt were included. Articles with pure BCG unresponsive

SUBMITTER:  

PROVIDER: S-EPMC10213538 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature