A prospective head-to-head comparison of [⁶⁸Ga]Ga-P16-093 and [⁶⁸Ga]Ga-PSMA-11 PET/CT in patients with primary prostate cancer.

ABSTRACT:

Purpose

We aimed to compare the diagnostic performance and biodistribution of two similar PET agents, [⁶⁸Ga]Ga-P16-093 and [⁶⁸Ga]Ga-PSMA-11, in the same group of primary prostate cancer (PCa) patients.

Methods

Fifty patients with untreated, histologically confirmed PCa by needle biopsy were enrolled. Each patient underwent [⁶⁸Ga]Ga-P16-093 and [⁶⁸Ga]Ga-PSMA-11 PET/CT within a week. In addition to visual analysis, the standardized uptake value (SUV) was measured for semiquantitative comparison and correlation analysis.

Results

[⁶⁸Ga]Ga-P16-093 PET/CT detected more positive tumors than [⁶⁸Ga]Ga-PSMA-11 PET/CT (202 vs. 190, P = 0.002), both for intraprostatic lesions (48 vs. 41, P = 0.016) and metastatic l

SUBMITTER: Wang G 

PROVIDER: S-EPMC10213584 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature