GATA6 regulates anti-angiogenic properties in human cardiac fibroblasts via modulating LYPD1 expression.

ABSTRACT:

Introduction

Fibroblasts contribute to the structure and function of tissue and organs; however, their properties differ in each organ given the topographic variation in gene expression among tissues. We previously reported that LYPD1, which is expressed in cardiac fibroblasts, has the capacity to inhibit sprouting of vascular endothelial cells. LYPD1 has been shown to be highly expressed in the human brain and heart, but the regulation of LYPD1 expression in cardiac fibroblasts has not been elucidated in detail.

Methods

To identify the LYPD1-modulating transcription factor, motif enrichment analysis and differential expressed gene analysis using microarray data were performed. Quantitative real-time PCR was used to evaluate gene expression. Gene silencing were perfor

SUBMITTER: Masuda S 

PROVIDER: S-EPMC10213613 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature