Glutamatergic neurons and GABAergic neurons of medial prefrontal cortex control hoarding-like behavior.

ABSTRACT: Hoarding disorder (HD) is a chronic disease that begins early in life and does not remission unless timely treated. A large number of factors affect the presentation of HD symptoms, including a strong possessive psychology of objects and neurocognitive functioning. However, the underlying neural mechanisms of the excessive hoarding behavior in HD are still unknown. Using viral infections and brain slice electrophysiology recordings, we found that increased glutamatergic neuronal activity and decreased GABAergic neuronal activity in medial prefrontal cortex (mPFC) accelerated the hoarding-like behavior in mice. Respectively, chemogenetic manipulation to reduce glutamatergic neuronal activity or enhance GABAergic neuronal activity could improve the hoarding-like behavioral response. These re

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC10213654 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature