Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner.

ABSTRACT: Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing the risk of fetal growth abnormalities and preeclampsia, gestational diabetes is associated with abnormalities in placental development including impairments in trophoblast differentiation. Given that metformin impacts cellular differentiation events in other systems, we assessed metformin's impact on trophoblast metabolism and differentiation. Using established cell culture models of trophoblast differentiation, oxygen consumption rates and relative metabolite abundance were determined following 200 µM (therapeutic range) and 2000 µM (supra-therapeutic range) metformin treatment using Seahorse and

SUBMITTER: Nashif SK 

PROVIDER: S-EPMC10213689 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature