A funnel-type stepwise filtering strategy for identification of potential Q-markers of traditional Chinese medicine formulas.

ABSTRACT: Quality marker (Q-marker) serves as an important driver for the standardization of quality control in traditional Chinese medicine (TCM) formulas. However, it is still challenging to discover comprehensive and representative Q-markers. This study aimed to identify Q-markers of Hugan tablet (HGT), a famous TCM formula with ideal clinical effects in liver diseases. Here, we proposed a funnel-type stepwise filtering strategy that integrated secondary metabolites characterization, characteristic chromatogram, quantitative analysis, literature mining, biotransformation rules and network analysis. Firstly, the strategy of "secondary metabolites-botanical drugs-TCM formula" was applied to comprehensively identify the secondary metabolites of HGT. Then, the secondary metabolites with specificity a

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10213786 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature