Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing.

ABSTRACT: Wound healing is a dynamic process that involves a series of molecular and cellular events aimed at replacing devitalized and missing cellular components and/or tissue layers. Recently, extracellular vesicles (EVs), naturally cell-secreted lipid membrane-bound vesicles laden with biological cargos including proteins, lipids, and nucleic acids, have drawn wide attention due to their ability to promote wound healing and tissue regeneration. However, current exploitation of EVs as therapeutic agents is limited by their low isolation yields and tedious isolation processes. To circumvent these challenges, bioinspired cell-derived nanovesicles (CDNs) that mimic EVs were obtained by shearing mesenchymal stem cells (MSCs) through membranes with different pore sizes. Physical characterisations and

SUBMITTER: Neupane YR 

PROVIDER: S-EPMC10213815 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature