From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer.

ABSTRACT: Tintelnot et al.¹ identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.

SUBMITTER: Seo YD 

PROVIDER: S-EPMC10213830 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature