Individualized QT interval (QTi) is a powerful diagnostic tool in long QT syndrome: results from a large validation study.

ABSTRACT:

Aims

Diagnosis of Long QT syndrome (LQTS) is based on prolongation of the QT interval corrected for heart rate (QTc) on surface ECG and genotyping. However, up to 25% of genotype positive patients have a normal QTc interval. We recently showed that individualized QT interval (QTi) derived from 24 h holter data and defined as the QT value at the intersection of an RR interval of 1,000 ms with the linear regression line fitted through QT-RR data points of each individual patient was superior over QTc to predict mutation status in LQTS families. This study aimed to confirm the diagnostic value of QTi, fine-tune its cut-off value and evaluate intra-individual variability in patients with LQTS.

Methods

From the Telemetric and Holter ECG Warehouse, 201 recordings from control indi

SUBMITTER: Robyns T 

PROVIDER: S-EPMC10213876 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature